DG-CST
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| - | The DG-CST database is a collection of conserved sequence elements, identified by a systematic genomic sequence comparison between a set of human genes involved in the pathogenesis of genetic disorders and their murine counterparts. Human and Mouse genomic sequences were compared by BLASTZ, an independent implementation of the Gapped BLAST algorithm, specifically designed for aligning two long genomic sequences | + | The DG-CST database is a collection of conserved sequence elements, identified by a systematic genomic sequence comparison between a set of human genes involved in the pathogenesis of genetic disorders and their murine counterparts. Human and Mouse genomic sequences were compared by BLASTZ, an independent implementation of the Gapped BLAST algorithm, specifically designed for aligning two long genomic sequences [http://bio.cse.psu.edu]. Sequences longer than 100 and with identity better than 70% were selected as CSTs and imported into the DB. CSTs are extensively annotated with respect to exon/intron structure and other biological parameters. |
| CST counterparts in other species were identified by using BLAST to scan genomes from other species, and selecting on the basis of homology and colinearity. | CST counterparts in other species were identified by using BLAST to scan genomes from other species, and selecting on the basis of homology and colinearity. | ||
Revision as of 18:07, 8 June 2007
The DG-CST database is a collection of conserved sequence elements, identified by a systematic genomic sequence comparison between a set of human genes involved in the pathogenesis of genetic disorders and their murine counterparts. Human and Mouse genomic sequences were compared by BLASTZ, an independent implementation of the Gapped BLAST algorithm, specifically designed for aligning two long genomic sequences [1]. Sequences longer than 100 and with identity better than 70% were selected as CSTs and imported into the DB. CSTs are extensively annotated with respect to exon/intron structure and other biological parameters. CST counterparts in other species were identified by using BLAST to scan genomes from other species, and selecting on the basis of homology and colinearity.
